gp130重组蛋白，ACROBiosystems百普赛斯

gp130产品信息

英文名称：Interleukin-6 receptor subunit beta

中文名称：白细胞介素-6β亚基

靶点别称：IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130

物种：Human / Mouse

标签：His Tag / Fc Tag

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

gp130分子背景

白细胞介素-6受体亚基β（IL6ST）也称为IL-6受体亚基α、IL-6R亚基β、IL-6Rβ、IL-6RB、白细胞介蛋白-6信号转导子、膜糖蛋白130（gp130）、CD130、Oncostatin-M受体亚基a和IL6ST，后者是单程I型膜蛋白。IL6ST/gp130/CD130可以在脑、心脏、胸腺、脾脏、肾脏、肺和肝脏等组织中发现，并且在除BaF-B03之外的所有测试细胞系中都有发现。IL-6ST/gp130的表达不限于IL6反应细胞。IL6、LIF、OSM、CNTF、IL11、CTF1和BSF3的受体系统可以利用gp130启动信号传输。IL6ST/CD130可以与IL6/IL6R（α链）复合物结合，形成高亲和力IL6结合位点，并转导信号。IL6ST/GP130不结合IL6，可能在胚胎发育中发挥作用。

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