VCAM1产品信息
英文名称：Vascular cell adhesion molecule 1
中文名称：血管细胞粘附分子1
靶点别称：VCAM1,CD106,INCAM-100,V-CAM 1,VCAM-1
物种：Human
标签：His Tag / Fc Tag / Fc Tag & Avi Tag
属性：Protein
标记：Biotin-labeled / Unconjugated
优势特色（Features）
1. Designed under ISO 9001:2015 and ISO 13485:2016
2. Manufactured and QC tested under a GMP compliance factory
3. Animal-Free materials
4. Batch-to-batch consistency
5. Stringent quality control tests
表达区间及表达系统（Source）
GMP Human VCAM-1 Protein, Fc Tag (GMP-VC1H25) is expressed from human 293 cells (HEK293). It contains AA Phe 25 - Glu 698 (Accession # P19320-1 ).
Predicted N-terminus: Phe 25
蛋白结构（Molecular Characterization）
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 100.7 kDa.
无菌（Sterility）
The sterility testing was performed by membrane filtration method described in CP<1101>, USP<71>and Eur. Ph. 2.6.1.
制剂（Formulation）
Please contact us for detailed information.
Contact us for customized product form or formulation.
重构方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储（Storage）
Shipping at ambient temperature. Upon receipt, store it immediately at -20°C or lower for long term storage.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 5 years in lyophilized state;
2. -70°C for 12 months under sterile conditions after reconstitution.
MANUFACTURING SPECIFICATIONS
ACROBiosystems GMP grade products are produced under a quality management system and in compliance with relevant guidelines: Ph. Eur General Chapter 5.2.12 Raw materials of biological origin for the production of cell-based and gene therapy medicinal products; USP<92>Growth Factors and Cytokines Used in Cell Therapy Manufacturing; USP<1043>Ancillary Materials for Cell, Gene, and Tissue-Engineered Products; ISO/TS 20399-1:2018, Biotechnology - Ancillary Materials Present During the Production of Cellular Therapeutic Products.
ACROBiosystems Quality Management System Contents：
1. Designed under ISO 9001:2015 and ISO 13485:2016, Manufactured and QC tested under a GMP compliance factory.
2. Animal-Free materials
3. Materials purchased from the approved suppliers by QA
4. ISO 5 clean rooms and automatic filling equipment
5. Qualified personnel
6. Quality-related documents review and approve by QA
7. Fully batch production and control records
8. Equipment maintenance and calibration
9. Validation of analytical procedures
10. Stability studies conducted
11. Comprehensive regulatory support files
ACROBiosystems provide rigorous quality control tests (fully validated equipment, processes and test methods) on our GMP grade products to ensure that they meet stringent standards in terms of purity, safety, activity and inter-batch stability, and each bulk QC lot mainly contains the following specific information:
1. SDS-PAGE
2. Protein content
3. Endotoxin level
4. Residual Host Cell DNA content
5. Residual Host Cell Protein content
6. Biological activity analysis
7. Microbial testing
8. Mycoplasma testing
9. In vitro virus assay
10. Residual moisture
11. Batch-to-batch consistency
DISCLAIMER
ACROBiosystems GMP grade products are designed for research, manufacturing use or ex vivo use. CAUTION: Not intended for human in vivo applications.
TERMS AND CONDITIONS
All products are warranted to meet ACROBiosystems Inc.’s (“ACRO”) published specifications when used under normal laboratory conditions.
ACRO DOES NOT MAKE ANY OTHER WARRANTY OR REPRESENTATION WHATSOEVER, WHETHER EXPRESS OR IMPLIED, WITH RESPECT TO ITS PRODUCTS. IN PARTICULAR, ACRO DOES NOT MAKE ANY WARRANTY OF SUITABILITY, NONINFRINGEMENT, MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE.
NOT WITH STANDING ANY OTHER PROVISIONS OF THESE TERMS AND/OR ANY OTHER AGREEMENT BETWEEN ACRO AND PURCHASER FOR THE PURCAHSE OF THE PRODUCTS, ACRO’S TOTAL LIABILITY TO PURCHASER ARISING FROM OR IN RELATION TO THESE TERMS, AN AGREEMENT BETWEEN THE PARTIES OR THE PRODUCTS, WHETHER ARISING IN CONTRACT, TORT OR OTHERWISE SHALL BE LIMITED TO THE TOTAL AMOUNT PAID BY PURCHASER TO ACRO FOR THE RELEVANT PRODUCTS. IN NO EVENT WILL ACRO BE LIABLE FOR THE COST OF PROCUREMENT OF SUBSTITUTE GOODS.
END USER TERMS OF USE OF PRODUCT
The following terms are offered to you upon your acceptance of these End User Terms of Use of Product. By using this product, you indicate your acknowledgment and agreement to these End User Terms of Use of Product. If you do not agree to be bound by and comply with all of the provisions of these End User Terms of Use of Product, you should contact your supplier of the product and make arrangements to return the product.
The End User is aware that ACROBiosystems Inc. and its affiliate (“ACRO”) sell GMP grade products designed for research, manufacturing use or ex vivo use and not intended for human in vivo applications. The End User further agrees, as a condition of the sales of ACRO’s GMP grade products that: a) the End User will not use this GMP grade product in any procedure wherein the product may be directly or indirectly administered to humans, unless the End User has obtained, or prior to their use will have obtained, an Investigational New Drug (IND) exemption from the FDA and will use the product only in accordance with the protocols of such IND and of the Institutional Review Board overseeing the proposed research, or b) the End User will use the products outside of the United States in accordance with the protocols of research approved by the applicable review board or authorized ethics committee and regulatory agencies to which the End User is subject to in their territory.
VCAM1分子背景
血管细胞粘附蛋白1（VCAM-1）也称为CD106、INCAM-100和L1CAM，是一种属于免疫球蛋白超家族的细胞表面唾液酸糖蛋白。VCAM-1/CD106含有7个Ig样C2型（免疫球蛋白样）结构域。CD106/VCAM-1在炎症的血管内皮细胞上表达，在正常和炎症组织中的巨噬细胞样细胞和树突状细胞类型上也表达。L1CAM/VCAM-1在细胞识别中很重要，似乎在白细胞-内皮细胞粘附中起作用。CD106/VCAM-1与白细胞上的β-1整合素VLA4相互作用，介导粘附和信号转导。VCAM-1/VLA4相互作用可能在免疫反应和白细胞向炎症部位迁移中发挥病理生理作用。INCAM-100/VCAM1与ECMV-D衣壳蛋白结合，并作为该病毒的受体。
