PLAU重组蛋白，ACROBiosystems百普赛斯

PLAU产品信息

英文名称：Urokinase plasminogen activator

中文名称：尿激酶型纤维蛋白溶酶原激活因子

靶点别称：Urokinase,PLAU

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 25 mM HEPES, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

PLAU分子背景

尿激酶型纤溶酶原激活剂也被称为PLAU和UPA，这是一种底物特异性极低的丝氨酸蛋白酶，切割纤溶酶原中的Cys-Pro-Gly-Arg560-Val561-Val-Gly-Gly-Cys序列形成纤溶酶。uPA是与乳腺癌、胃癌、结肠癌、膀胱癌、卵巢癌、脑癌和子宫内膜癌相关的各种人类癌症侵袭和转移的有力标志物。uPA及其受体（uPAR）与广泛的病理生理过程有关，包括纤维蛋白溶解、蛋白解解、炎症、动脉粥样硬化和斑块失稳，所有这些都与心肌梗死的发病机制有关。

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