CD8a重组蛋白，ACROBiosystems百普赛斯

CD8a产品信息

英文名称：Cluster of differentiation 8

中文名称：分化群8

靶点别称：CD8 Antigens,CD8a,CD8 alpha

物种：Human / Mouse / Cynomolgus

属性：Protein

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

CD8a分子背景

在免疫反应中起重要作用的完整膜糖蛋白，在抵抗外部和内部攻击的反应中具有多种功能。同时与T细胞受体（TCR）和抗原呈递细胞（APC）呈递的MHC I类蛋白相互作用。反过来，Src激酶LCK被募集到TCR-CD3复合物附近。在NK细胞中，细胞表面CD8A同源二聚体的存在提供了一种存活机制，允许多个靶细胞的结合和裂解。CD8A同二聚体分子还促进活化淋巴细胞的存活和分化为记忆性CD8 T细胞。