白介素15受体/IL15RA重组蛋白，ACROBiosystems百普赛斯

IL-15RA产品信息

英文名称：Interleukin-15 receptor subunit alpha

中文名称：白细胞介素-15受体α亚基

靶点别称：IL-15 R alpha,CD215,IL15RA,IL-15RA,IL-15R-alpha

物种：Human / Mouse

属性：Protein

标记：Biotin-labeled / FITC Labeled / Unconjugated / PE Labeled

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

IL-15RA分子背景

IL15R是IL15RA、IL2RB和IL2RG的异三聚体。IL-15RA，也称为CD215、IL-15Rα，是一种广泛表达的60kDa跨膜糖蛋白。白细胞介素-15的高亲和力受体。可以顺式和反式信号，其中来自一个细胞亚群的IL15R将IL15呈递给相邻的IL2RG表达细胞。不同异构体的表达可能会改变或干扰信号转导。白细胞介素（IL）-15超激动剂/IL-15受体α融合复合物（IL-15SA/IL-15RA；ALT-803）激活CD8 T细胞和NK细胞上的IL-15受体，并显示出显著的抗肿瘤作用。信号转导涉及SYK。与膜结合形式相比，可溶性sIL-15RA形式在所有脑结构中都存在更高水平。

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