补体C3/Complement C3，ACROBiosystems百普赛斯

Complement C3产品信息

英文名称：Complement C3

中文名称：补体C3

靶点别称：Complement C3,CPAMD1

物种：Human / Mouse / Cynomolgus

属性：Protein

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Complement C3分子背景

补体C3是血清中的主要补体成分。它主要由巨噬细胞和肝脏合成。C3在补体系统的激活中起着核心作用。C3转化酶对其的处理是经典和替代补体途径的核心反应。它被切割成两个片段，C3a和C3b。C3a过敏毒素是局部炎症过程的介质。在慢性炎症中，充当中性粒细胞的化学引诱剂。激活后，C3b可以通过其反应性硫酯与细胞表面碳水化合物或免疫聚集体共价结合。它诱导平滑肌收缩，增加血管通透性，并导致肥大细胞和嗜碱性白细胞释放组胺。

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