IL-23R重组蛋白，ACROBiosystems百普赛斯

IL-23R产品信息

英文名称：Interleukin 23 Receptor

中文名称：白细胞介素23受体

靶点别称：IL-23 R,IL-23 Receptor

物种：Human / Mouse / Cynomolgus

属性：Protein

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

IL-23R分子背景

白细胞介素23受体（IL-23R）是一种I型细胞因子受体，IL-23R与受体分子IL12RB1/IL12Rbeta1配对，两者都是IL23A信号传导所必需的。此外，IL-23R与Janus激酶2（JAK2）组成型结合，并以配体依赖的方式与转录激活因子STAT3结合。此外，IL-23R可能通过激活Jak-Stat信号级联来介导T细胞、NK细胞和某些巨噬细胞/髓系细胞的刺激。至于IL-23，它可能与自身免疫性炎症性疾病有关，对肿瘤发生很重要。

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