GFR alpha-like，ACROBiosystems百普赛斯

GFR alpha-like产品信息

英文名称：GDNF family receptor alpha-like

靶点别称：GFR alpha like,GFR alpha-like,GFRAL,GRAL

物种：Human / Mouse / Cynomolgus / Rat

属性：Protein / Antibody Licensing

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

GFR alpha-like分子背景

GFRα样也称为GDNF家族受体α样、GFRAL、C6orf144、UNQ9356、PRO34128。生长分化因子-15（GDF15）是一种循环蛋白，与多种生物学过程有关，包括能量稳态、体重调节和癌症和慢性病引起的恶病质。GDNF家族受体α样（GFRAL）最近被确定为负责介导GDF15厌食作用的神经元脑干受体。GDF15的脑干限制性受体，在代谢和毒素诱导的压力下调节食物摄入、能量消耗和体重。GDF15与其配体相互作用后，与RET相互作用，并通过激活MAPK和AKT信号通路诱导细胞信号传导。