ENPP3重组蛋白，ACROBiosystems百普赛斯

ENPP3产品信息

英文名称：Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

中文名称：核苷酸内焦磷酸酶/磷酸二酯酶家族成员-3

靶点别称：ENPP3,CD203c,NPP3,E-NPP3,PD-Ibeta,NPPase,PDNP3

物种：Human / Mouse

属性：Protein / Cell

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50mM Tris, 150mM NaCl, pH 7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

ENPP3分子背景

人源NPP家族包含七名成员，根据其底物偏好可分为两组。第一类包括核苷酸降解蛋白NPP1、3和4。NPP3（CD203c，ENPP3）在多个器官中表达，包括上皮和粘膜表面，尤其是嗜碱性粒细胞和肥大细胞。抗原结合的IgE激活嗜碱性粒细胞导致炎症介质的释放和NPP3向细胞表面的快速上调。事实上，这种蛋白质是通过流式细胞术诊断患者嗜碱性粒细胞过敏原敏感性的常见标志物。嗜碱性粒细胞和肥大细胞介导对某些病原体的反应，以及急性和慢性过敏反应。激活后，这些细胞释放ATP，ATP以自分泌的方式进一步刺激它们。NPP3上调有助于降解ATP并抑制慢性过敏性炎症（但不是急性反应）。