白介素31/IL-31，ACROBiosystems百普赛斯

IL-31产品信息

英文名称：Interleukin-31

中文名称：白介素31

靶点别称：IL-31,IL31

物种：Human / Mouse / Cynomolgus

属性：Protein

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

IL-31分子背景

IL-31是一种炎性细胞因子，有助于引发针对病原体的细胞介导免疫。通过由IL31RA和OSMR组成的IL31异二聚体受体激活STAT3，并可能激活STAT1和STAT5。它也被确定为包括特应性皮炎在内的许多慢性炎症性疾病的主要参与者。可能对皮肤免疫起作用。IL-31由多种细胞产生，即2型辅助（TH2）T细胞。IL-31通过由IL-31RA和在免疫细胞和上皮细胞中表达的抑瘤素M受体β（OSMRβ）组成的受体复合物发送信号。这些信号激活三条通路：ERK1/2 MAP激酶、PI3K/AKT和JAK1/2信号通路。

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