整合素Integrin αvβ1，ACROBiosystems百普赛斯

Integrin αvβ1产品信息

英文名称：Integrin alpha-V/beta-1

中文名称：整合素α-V/β-1复合体

靶点别称：Integrin αvβ1,Integrin alpha V beta 1,ITGAV&ITGB1

物种：Human / Cynomolgus / Rat

属性：Protein

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 8.0 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Integrin αvβ1分子背景

整合素α-5/β-1是纤维蛋白原的受体。整合素α-1/β-1、α-2/β-1，α-6/β-1和α-7/β-1是lamimin的受体。整合素α-4/β-1是VCAM-1的受体。它识别VCAM-1中的序列Q-I-D-S。整合素α-9/β-1是VCAM-1、细胞触觉素和骨桥蛋白的受体。它识别细胞触觉素中的序列A-E-I-D-G-I-E-L。整合素α-V/β-1也是玻连蛋白的受体。Beta-1整合素在多种配体中识别R-G-D序列。异构体2干扰异构体1，对细胞粘附和迁移（体外）产生显性负面影响。当与α-7/β-1整合素结合时，调节细胞粘附和层粘连蛋白基质沉积。