MAdCAM1重组蛋白，ACROBiosystems百普赛斯

MAdCAM-1产品信息

英文名称：Mucosal addressin cell adhesion molecule-1

中文名称：黏膜地址素细胞黏附分子-1

靶点别称：MAdCAM-1,MAdCAM1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

物种：Human

属性：Protein

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

MAdCAM-1分子背景

粘膜寻址蛋白细胞粘附分子-1（MAdCAM-1）在炎症性疾病中淋巴细胞向炎症部位的内皮粘附和迁移中起着关键作用。体外和体内数据表明，阻断粘附分子-细胞粘附分子中的粘膜寻址（MAdCAM）通路通过抑制MAdCAM与其配体α4β7整合素在淋巴细胞上表达的相互作用，减少白细胞归巢到肠道。