B7-H4重组蛋白，ACROBiosystems百普赛斯

B7-H4产品信息

英文名称：V-set domain-containing T-cell activation inhibitor 1
中文名称：含V区域T细胞激活抑制因子1
靶点别称：B7-H4,VTCN1,B7S1,B7h.5

物种：Human / Mouse / Cynomolgus / Rhesus macaque / Rat / Canine

属性：Protein / Cell

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

B7-H4分子背景

含V集结构域的T细胞活化抑制剂1（VTCN1）也称为免疫共刺激蛋白B7-H4、蛋白B7S1、T细胞共刺激分子B7x、B7H4，属于免疫球蛋白超家族和BTN/MOG家族。VTCN1含有两个Ig样V型（免疫球蛋白样）结构域。IL6和IL10上调VTCN1的表达，GM-CSF和IL4抑制抗原呈递细胞（APCs）上的VTCN1表达。VTCN1/B7-H4通过抑制T细胞活化、增殖、细胞因子产生和细胞毒性的发展，负调控T细胞介导的免疫反应。VTCN1参与促进上皮细胞转化。

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