CD20重组蛋白，ACROBiosystems百普赛斯

CD20产品信息

英文名称：B-lymphocyte antigen CD20

中文名称：B淋巴细胞抗原CD20

靶点别称：MS4A1，CD20

物种：Human / Mouse / Cynomolgus / Rabbit / Canine

属性：Protein / Antibody / Cell

标记：Biotin-labeled / Unconjugated / GFP Fusion

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>85% as determined by SDS-PAGE.

制剂（Formulation）

This product is not suitable for cell based experiments due to cytotoxicity of DDM.

DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove DDM and CHS.

DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.

If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. The product MUST be stored at -70°C or lower upon receipt;

2. -70°C for 3 months under sterile conditions.

CD20分子背景

B淋巴细胞抗原CD20也称为B淋巴细胞表面抗原B1、白细胞表面抗原Leu-16、跨膜4结构域亚家族A成员1和MS4A1，是一种活化的糖基化磷蛋白，从B前相（CD45R+、CD117+）开始在所有B细胞表面表达，浓度逐渐增加，直到成熟。CD20在B细胞发育的所有阶段都有表达，除了第一个和最后一个阶段；它从晚期pro-B细胞通过记忆细胞存在，但不存在于早期pro-B细胞或浆母细胞和浆细胞上。在B细胞淋巴瘤、毛细胞白血病、B细胞慢性淋巴细胞白血病和黑色素瘤癌症干细胞中发现。该蛋白没有已知的天然配体，其功能是实现最佳的B细胞免疫反应，特别是针对T非依赖性抗原。怀疑它在细胞膜中充当钙通道。CD20/MS4A1是单克隆抗体（mAb）利妥昔单抗、伊维单抗和托西莫单抗的靶点，这些抗体都是治疗所有B细胞淋巴瘤和白血病的活性药物。CD20/MS4A1的缺陷是免疫缺陷共同变量5型（CVID5）的原因；也称为由于CD20缺陷引起的抗体缺乏症。CVID5是一种原发性免疫缺陷，其特征是抗体缺乏、低丙种球蛋白血症、反复细菌感染和无法对抗原产生抗体反应。

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