Fc gamma RIIA / CD32a ACROBiosystems百普赛斯

Fc gamma RIIA / CD32a信息

英文名称：Low affinity immunoglobulin gamma Fc region receptor II-a

中文名称：低亲和力免疫球蛋白γFc区受体II-a

靶点别称：CD32a，FCGR2A，CD32，FCG2，FCGR2A1，IGFR2

物种：Human / Cynomolgus / Rat / Rhesus macaque

属性：Protein / Cell

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70^°C for 12 months under sterile conditions after reconstitution.

Fc gamma RIIA / CD32a分子背景

IgG Fc区受体（FcγR）是Ig超家族的成员，在激活或抑制免疫反应中发挥作用。识别出三类人FcγRs：RI（CD64）、RII（CD32）和RIII（CD16），它们产生多种亚型。人类FcγRII/CD32有三个基因（A、B和C），小鼠FcγRII B有一个基因（CD32B）。CD32是IgG的低亲和力受体。激活亚型CD32A在单核细胞、中性粒细胞、血小板和树突状细胞上表达。CD32A在许多免疫细胞类型（巨噬细胞、中性粒细胞、嗜酸性粒细胞、血小板、树突状细胞和Langerhan细胞）上表达，其中携带抑制性ITIM的受体也可能与特定配体共表达和共结合。CD32A在配体结合时传递激活信号，并导致炎症反应的启动，包括细胞溶解、吞噬、脱颗粒和细胞因子的产生。反应可以通过来自共表达的抑制性受体（如CD32B）的信号来调节，信号的强度取决于激活和抑制性受体的表达比率。

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