B7-H3/CD276蛋白 ACROBiosystems百普赛斯

B7-H3信息

英文名称：CD276 antigen

中文名称：CD276抗原

靶点别称：B7-H3，CD276，B7 homolog 3

物种：Human / Mouse / Cynomolgus

属性：Protein / Cell / Beads / Licensing / Antibody Licensing

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 24 months in lyophilized state;

2. -70^°C for 24 months under sterile conditions after reconstitution.

B7-H3分子背景

B7同源物3（B7-H3）是免疫球蛋白超家族的成员，也被称为CD276，它包含两个Ig样C2型（免疫球蛋白样）结构域和两个Ig型V型（免疫蛋白样）的结构域。B7-H3可能参与调节T细胞介导的免疫反应。B7-H3还通过抑制自然杀伤介导的细胞裂解在肿瘤细胞中发挥保护作用，并作为检测神经母细胞瘤细胞的标志物。此外，B7-H3参与急性和慢性移植排斥反应的发展以及粘膜表面淋巴细胞活性的调节。它还可以在整个怀孕期间为胎盘和胎儿提供合适的免疫环境方面发挥关键作用。

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