TNF-alpha蛋白 ACROBiosystems百普赛斯

TNF-alpha产品信息

英文名称：Tumor necrosis factor α

中文名称：肿瘤坏死因子α

靶点别称：TNF-alpha,TNFSF2,TNFA,TNF-α

物种：人/鼠/犬等

属性：重组蛋白/抗体/试剂盒

标记：Biotin-labeled / Unconjugated / HRP Labeled

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1.  -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

TNF-alpha分子背景

肿瘤坏死因子α（TNFα）是一种主要由单核细胞和巨噬细胞产生的细胞因子。它存在于滑膜细胞和组织中的巨噬细胞中。TNFα的主要作用是调节免疫细胞。TNFα能够诱导细胞凋亡、诱导炎症、抑制肿瘤发生和病毒复制。TNFα产生的失调与多种人类疾病有关，包括严重抑郁症、阿尔茨海默病和癌症。重组TNFα作为免疫刺激剂在INN tasonermin下使用。TNFα可在恶性肿瘤中异位产生，在引起继发性高钙血症和与过量产生相关的癌症中与甲状旁腺激素相似。

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