DLL3重组蛋白 ACROBiosystems百普赛斯

英文名称：Delta-like protein 3
中文名称：δ样蛋白-3
靶点别称：Delta-Like Protein 3，Delta3，Delta-Like 3，Drosophila Delta Homolog 3，SCDO1，Delta-Like 3 (Drosophila)，DLL3，Delta (Drosophila)-Like 3，Delta Like Canonical Notch Ligand 3

表达区间及表达系统（Source）

Human DLL3, His Tag (DL3-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Leu 492 (Accession # Q9NYJ7-1 ).

Predicted N-terminus: Ala 27

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 50.4 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS with Arginine, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

分子背景（Background）

Delta-like protein 3（DLL3）是一种跨膜蛋白，属于Notch配体的Delta/Serrate/Lag-2 (DSL)家族。可能需要沿着特定的分化途径转移神经元。在轴旁中胚层分割过程中，在体节边界的形成中发挥作用。DLL3蛋白在肿瘤细胞表面表达，但在正常成人组织中不表达。

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