aladdin 阿拉丁 T408390 桔皮素 481-53-8 10mM in DMSO

中文名：桔皮素

英文名：Tangeretin

英文别名：Tangeritin;4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-

纯度：10mM in DMSO

货号：T408390

包装：1ml

Cas号：481-53-8

存储温度：-80℃储存

产品介绍：

Information

Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.
In vitro

Tangeretin is a polymethoxylated flavonoid concentrated in the peel of citrus fruits. Recent studies have shown that tangeretin exhibits anti-proliferative, anti-invasive, anti-metastatic, and antioxidant activities. Tangeretin at 2.7 μM induces apoptosis in human promyelocytic leukaemia HL-60 cells, whereas the flavone showed no cytotoxicity against human peripheral blood mononuclear cells (PBMCs). Further study shows that tangeretin at 50 μM exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins such as Cdk2 and Cdk4, and mediates the increase of Cdk inhibitors p21 and p27. Pretreatment with tangeretin inhibites IL-1beta-induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB in human lung epithelial carcinoma cells (A549) and and human non-small cell lung carcinoma cells (H1299).

In vivo

Cell Data

cell lines：

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Incubation Time：

Powder Purity:≥97%

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