aladdin 阿拉丁 N408931 尼伐地平 75530-68-6 10mM in DMSO
75530-68-6
产品详情:
- 中文名称:
- 尼伐地平
- 英文名称:
- Nilvadipine
- CAS号:
- 75530-68-6
- 品牌:
- 阿拉丁
- 产地:
- 上海
- 保存条件:
- -80℃储存
- 纯度规格:
- 10mM in DMSO
- 产品类别:
- 药靶配体 药靶配体
- 分子式:
- C19H19N3O6
- 分子量:
- 385.37
- 运输条件:
- 超低温冰袋运输
- 产品规格:
- 1ml
- 货号:
- N408931
- 是否进口:
- 否
中文名:尼伐地平
英文名:Nilvadipine
英文别名:ARC029, FR34235;5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
纯度:10mM in DMSO
货号:N408931
包装:1ml
Cas号:75530-68-6
存储温度:-80℃储存
产品介绍:
Information
Nilvadipine Nilvadipine (ARC029, FR34235) is a potent calcium channel blocker with an IC50 of 0.03 nM.
In vitro
Nilvadipine strongly inhibits the chemotaxis of interleukin-1 (IL-1), leukotriene B4 (LTB4), platelet-derived growth factor (PDGF) with IC50 of 0.1 nM in rat aortic smooth muscle cells (SMC). Nilvadipine is reported to increase renal blood flow and reduce filtration fraction in the isolated perfused hydronephrotic kidney, suggesting indirectly afferent and efferent arteriolar vasodilation.
In vivo
Nilvadipine preserves retinal morphology and electroretinogram responses in RCS rats during the initial stage of retinal degeneration. Nilvadipine significantly enhances rhodopsin kinase and alphaA-crystallin expression and suppression of caspase 1 and 2 expression in the retina of RCS rats. Nilvadipine completely inhibits the vasoactivity elicited by Abeta in rat aortae and in human middle cerebral arteries. Nilvadipine restores cortical perfusion levels in Tg APPsw to values similar to those observed in control littermates without notably affecting the CBF of control mice. Nilvadipine suppresses ischemia (20 min)-reflow (20 min)-induced paw edema of mice (ED30:0.4 mg/kg i.v. and 2 mg/kg p.o.). Nilvadipine suppresses carrageenan-induced paw edema (ED30:15 mg/kg in rats and 20 mg/kg in mice) at a potency corresponding to that of an anti-inflammatory drug, ibuprofen. Nifedipine, nicardipine and nimodipine results in a suppression of 30% only with 100 mg/kg oral dosing in rats. Nilvadipine inhibits superoxide radical (O-2production from xanthine oxidase (XOD) both with lactate dehydrogenase + NADH method and cytochrome c method (IC50:90 and 100 mg/mL, respectively).
Cell Data
cell lines:
Concentrations:
Incubation Time:
Powder Purity:≥99%
查看阿拉丁官网此产品相关对应页面:https://www.aladdin-e.com/zh_cn/N408931.html
公司简介
成立日期 | (16年) |
注册资本 | 14130.676万人民币 |
员工人数 | 500人以上 |
年营业额 | ¥ 1亿以上 |
经营模式 | 工厂,试剂 |
主营行业 | 生物化工,化学试剂 |
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