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  • aladdin 阿拉丁 M408440 MPTP hydrochloride 23007-85-4 10mM in DMSO

aladdin 阿拉丁 M408440 MPTP hydrochloride 23007-85-4 10mM in DMSO

MPTP hydrochloride
23007-85-4
299.90 1ml 起订
上海 更新日期:2024-11-29

上海阿拉丁生化科技股份有限公司

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产品详情:

中文名称:
MPTP hydrochloride
英文名称:
MPTP hydrochloride
CAS号:
23007-85-4
品牌:
阿拉丁
产地:
上海
保存条件:
-80℃储存
纯度规格:
10mM in DMSO
产品类别:
药靶配体 药靶配体
分子式:
C12H15N·HCl
分子量:
209.72
运输条件:
超低温冰袋运输
产品规格:
1ml
货号:
M408440
是否进口:

中文名:MPTP hydrochloride

英文名:MPTP hydrochloride

纯度:10mM in DMSO

货号:M408440

包装:1ml

Cas号:23007-85-4

存储温度:-80℃储存

产品介绍:

Information

MPTP hydrochloride is a dopaminergicneurotoxinand cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride inducesapoptosis.
In vitro

The morphology of N2AB-1 and glioma cells was unaltered when these cells were exposed to all doses of MPTP. And, C6 glioma cell proliferation was also unaffected by MPTP treatment[3]. MPTP Promotes Apoptosis and Tau Phosphorylation in Human Neuroblastoma M17 Cells. MPTP significantly promotes Tau phosphorylation at Ser262 in human neuroblastoma M17 cells. MPTP caused a dose-dependent increase in the intracellular α-synuclein level in our M17 human neuroblastoma cells. MPTP appears to promote Tau phosphorylation in the brain by activating both PKA and GSK3β[4].\n

In vivo

The number of tyrosine hydroxylase-positive neurons was decreased in the substantia nigra pars compacta of MPTP-treated mice. MPTP decreased thioredoxin reductase 1 expression and thioredoxin reductase activity in the mouse midbrain, reduced the number of thioredoxin reductase 1-positive cells in the substantia nigra pars compacta of mice. Administration of the toxin MPTP can cause neurochemical, behavioral and histopathological alterations in human and nonhuman primates that are similar to those observed in Parkinsonian patients. Compared with primates, rodents are insensitive to MPTP. MPTP can be administered by various routes, such as gavage and stereotactic injection, but the most common and reproducible route is systemic administration, including subcutaneous, intravenous, intraperitoneal and intramuscular injection. MPTP is a lipophilic protoxin that can rapidly cross the blood-brain barrier following systemic injection. Once it enters the brain, MPTP is converted to 1-methyl-4-phenylpyridine by monoamine oxidase B[1]. MPTP has been shown to be toxic to dopaminergic neurons of the nigrostriatal system in humans, monkeys, and mice and to produce long-lasting depletion of DA and its metabolites in the striatum[2].
Cell Data

cell lines:

Concentrations:', 'Concentrations': '

47.7, 4.77 and 0.477 μM

Incubation Time:

Powder Purity:

查看阿拉丁官网此产品相关对应页面:https://www.aladdin-e.com/zh_cn/M408440.html


MPTP hydrochloride;MPTP hydrochloride;23007-85-4

公司简介

上海阿拉丁生化科技股份有限公司是A股上市公司((股票代码:688179),专注于科研试剂的研发、生产和销售,已陆续建立多个工厂和研发中心。作为领军企业,阿拉丁始终坚持质量第一,连续13年被评为“最受欢迎试剂品牌”。 阿拉丁目前常备库存试剂产品品种超过7万种,SKU总数超过46万,产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域,是国内少数化学试剂到生物试剂全面发展的国产试剂品牌,产品同步发布在我们国内外电商平台。

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经营模式 工厂,试剂
主营行业 生物化工,化学试剂

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