aladdin 阿拉丁 H275171 萜烯七脂酸 74310-84-2 ≥95%

中文名：萜烯七脂酸

英文名：Heptelidic acid (Koningic acid)

中文别名：(5aS,6R,9S,9aS)-1-氧-6-丙-2-基螺[3,5a,6,7,8,9a-六氢-2-苯并xepine-9,2'-环氧乙烷]-4-羧酸|(+)-萜烯七脂酸

纯度：≥95%

货号：H275171

包装：1mg

Cas号：74310-84-2

存储温度：-20°C储存,干燥

产品介绍：

product description：

Antibiotic .

Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH .

Anticancer compound . Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation .

Antimalarial .

Apoptosis inhibitor. DNA fragmentation and caspase-3 activation inhibitor .

Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols .

Reduces lactate secretion and causes reductions in overall protein synthesis and production of IFN-α and TNF.

application：

Heptalidic acid is a sesquiterpene lactone and found to inhibit etoposide-induced apoptosis in human leukemia U937 cells. In addition, it also inhibit mammalian DNA polymerases and terminal deoxynucleotidyl transferase.

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