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  • aladdin 阿拉丁 F408356 盐酸非索非那定 153439-40-8 10mM in DMSO

aladdin 阿拉丁 F408356 盐酸非索非那定 153439-40-8 10mM in DMSO

Fexofenadine HCl
153439-40-8
720.90 1ml 起订
上海 更新日期:2025-02-27

上海阿拉丁生化科技股份有限公司

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产品详情:

中文名称:
盐酸非索非那定
英文名称:
Fexofenadine HCl
CAS号:
153439-40-8
品牌:
阿拉丁
产地:
上海
保存条件:
-80℃储存
纯度规格:
10mM in DMSO
产品类别:
药靶配体 药靶配体
分子式:
C32H39NO4·HCl
分子量:
538.12
运输条件:
超低温冰袋运输
产品规格:
1ml
货号:
F408356
是否进口:

中文名:盐酸非索非那定

英文名:Fexofenadine HCl

英文别名:MDL 16455A;Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride (1:1)

纯度:10mM in DMSO

货号:F408356

包装:1ml

Cas号:153439-40-8

存储温度:-80℃储存

产品介绍:

Information

Fexofenadine (MDL 16455A) inhibitshistamine H1receptor withIC50of 246 nM.
In vitro

Fexofenadine exhibits a potent and concentration-dependent anti-anaphylactic activity with an IC50 value of 95.5nM. Fexofenadine shows only a weak competitive antagonist behaviour for the 5-HT2A receptorsfrom rat caudal artery with pA2 of 5.2. All four P-gp inhibitors has a strong, concentration-dependent effect on the Papp of fexofenadine in both directions in the Caco-2 cell model. The IC50 of verapamil is 8.44 mM on the P-gp-mediated secretion of Fexofenadine. Fexofenadine causes a significant increase in the QT and Tp-e intervals and receives a significant TdP score at doses greater than 100 fold its free TPC in the rabbit left ventricular wedge preparation.

In vivo

Fexofenadine is excreted unchanged in the urine, bile, and gastrointestinal tract, indicating minimal metabolism in rats, making it an ideal probe to study transport processes. Coadministration of Fexofenadine with Ketoconazole increases the oral exposure of Fexofenadine by 187% in rats. In contrast, coadministration of Fexofenadine with orange juice or apple juice to rats decreases the oral exposure of Fexofenadine by 31% and 22%, respectively. Increasing the quantity of orange or apple juice administered further decreases the oral exposure of Fexofenadine, by 40% and 28%, respectively. Biliary excretion clearance of Fexofenadine (17 ml/min/kg) accounts for almost 60% of the total body clearance (30 ml/min/kg) in mice. Knockout mice of Mdr1a/1b P-gp does not affect the biliary excretion clearance with regard to both plasma and liver concentrations, whereas the absence of P-gp causes a 6-fold increase in the plasma concentration and 3-fold higher brain-to-plasma concentration ratio after oral administration.
Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

查看阿拉丁官网此产品相关对应页面:https://www.aladdin-e.com/zh_cn/F408356.html


MDL 16455A;Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride (1:1)

公司简介

上海阿拉丁生化科技股份有限公司是A股上市公司((股票代码:688179),专注于科研试剂的研发、生产和销售,已陆续建立多个工厂和研发中心。作为领军企业,阿拉丁始终坚持质量第一,连续13年被评为“最受欢迎试剂品牌”。 阿拉丁目前常备库存试剂产品品种超过7万种,SKU总数超过46万,产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域,是国内少数化学试剂到生物试剂全面发展的国产试剂品牌,产品同步发布在我们国内外电商平台。

成立日期 (16年)
注册资本 14130.676万人民币
员工人数 500人以上
年营业额 ¥ 1亿以上
经营模式 工厂,试剂
主营行业 生物化工,化学试剂

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