aladdin 阿拉丁 C408520 Crizotinib (PF-02341066) 877399-52-5 10mM in DMSO

中文名：克唑替尼

英文名：Crizotinib

纯度：≥99%

货号：C137735

Cas号：877399-52-5

存储温度：2-8°C储存

运输条件：低温运输

产品介绍：

PF-2341066 shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. PF-2341066 shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. PF-2341066 supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. PF-2341066 induces apoptosis in GTL-16 cells with an IC5050 of 30 nM.

A Met inhibitor effective against various cell lines

Crizotinib has been used:

· to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis

· to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells

· to restore sensitivity to erlotinib

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