aladdin 阿拉丁 G287870 GTP 14564,III类受体酪氨酸激酶（RTK）抑制剂 34823-86-4 99%

中文名：GTP 14564,III类受体酪氨酸激酶（RTK）抑制剂

英文名：GTP 14564

纯度：Moligand™，≥99%

货号：G287870

Cas号：34823-86-4

存储温度：避光,-20°C储存

运输条件：超低温运输

产品介绍：

Product description：

A cell-permeable, reversible, ATP-competitive, and tricyclic, benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 300 nM for c-fms, c-kit, wt-FLT3, and internal tandem duplication (ITD)-FLT3; 1 µM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, Akt, PKC, MEK, or ERK1/2 (IC50 >10 µM). Inhibits FLT-3 ligand-dependent growth of Ba/F3 cells expressing wild type FLT-3. Reported to be useful in differentiating signal transduction pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.

A cell-permeable, reversible, and ATP-competitive tricyclic benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 0.3 µM for c-fms, c-kit, wt-FLT3 and ITD-FLT3; 1.0 µM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, AKT, PKC, MEK, or ERK1/2 (IC50 ≥ 10 µM). Has been used successfully to differentiate between the signalling pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/G287870.html