aladdin 阿拉丁 M413961 MKC-3946 1093119-54-0 99%

中文名：MKC-3946

英文名：MKC-3946

英文别名：1-​Naphthalenecarboxald​ehyde,2-​hydroxy-​6-​[5-​[(4-​methyl-​1-​piperazinyl)​carbonyl]​-​2-​thienyl]​-

纯度：99%

货号：M413961

包装：25mg、2mg、5mg

Cas号：1093119-54-0

存储温度：-20°C储存

产品介绍：

Information

MKC-3946 MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.

Targets

IRE1α endoribonuclease

In vitro

MKC-3946 triggers modest growth inhibition in MM cell lines, without toxicity in normal mononuclear cells. Importantly, it significantly enhances cytotoxicity induced by bortezomib or 17-AAG, even in the presence of bone marrow stromal cells or exogenous IL-6. Both bortezomib and 17-AAG induce ER stress, evidenced by induction of XBP1s, which is blocked by MKC-3946. Apoptosis induced by these agents is enhanced by MKC-3946, associated with increased CHOP. MKC-3946 treatment does not inhibit IRE1α kinase function or binding of activated IRE1α to TRAF2 and downstream JNK signaling.

In vivo

MKC-3946 inhibits XBP1 splicing in a model of ER stress associated with significant growth inhibition of MM cells.

Cell Research(from reference)

Cell lines：RPMI 8226 cells 

Concentrations：2.5, 5, 10 μM 

Incubation Time：3 hours 

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