aladdin 阿拉丁 M413517 ML355 1532593-30-8 98%

中文名：ML355

英文名：ML355

纯度：Moligand™，≥98%

货号：M413517

Cas号：1532593-30-8

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

ML355 ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases.

Targets

12-LOX

In vitro

ML355 displays nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases.

In vivo

In vivo PK studies where ML355 is administered as a solution via IV (3mpk) and PO (30mpk) demonstrated that ML355 is orally bioavailable (%F = 20) with good half-life (T1/2 = 2.9 hours). At 30 mpk dosing, ML355 achieves a Cmax of over 135 times the in vitro IC50 and remains over IC50 value for over 12 hours. The compound has low clearance (3.4 mL/min/kg) and good overall exposure (AUCinf) of 38 µM. Although, the volume of distribution (VD) observed is low (0.55 L/kg), the rest of the PK profiling results suggest a reasonable distribution between tissue and blood.

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