aladdin 阿拉丁 T414018 TAK-063 1238697-26-1 98%

中文名：TAK-063

英文名：TAK-063

纯度：≥98%

货号：T414018

Cas号：1238697-26-1

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

TAK-063 (Balipodect) is a novel and selectivephosphodiesterase 10A(PDE10A)inhibitor with an IC50 of 0.30 nM.

Targets

PDE10A (Cell-free assay) 0.3 nM

In vivo

TAK-063 has high brain penetration in mice. Oral administration of TAK-063 to mice elevated striatal cAMP and (cGMP) levels at 0.3 mg/kg and shows potent suppression of phencyclidine (PCP)-induced hyperlocomotion at a minimum effective dose (MED) of 0.3 mg/kg. TAK-063 is currently being evaluated in clinical trials for the treatment of schizophrenia.

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