aladdin 阿拉丁 L414198 LIT-927 2172879-52-4 99%

中文名：LIT-927

英文名：LIT-927

英文别名：LIT-927|2172879-52-4|4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1H)-one|LIT927|CHEMBL4166454|6-(4-chlorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-1H-pyrimidin-2-one|SCHEMBL19782686|GTPL10075|LIT 927|DTXSID001162146|LIT 927; LIT927|BCP29866|EX

纯度：99%

货号：L414198

包装：25mg、5mg、100mg

Cas号：2172879-52-4

存储温度：-20°C储存

产品介绍：

Information

LIT-927 is a novel neutraligand ofCXCL12with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.

Targets

CXCR4 ; CXCL12 ; 267 nM(Ki)

In vitro

LIT-927 is able to bind selectively CXCL12 and to inhibit CXCL12-CXCR4 interaction.

In vivo

In a murine model of hypereosinophilia, LIT-927 shows a large and statistically reliable inhibition of eosinophil recruitment. It inhibits allergic eosinophilic airway inflammation in mice when administered orally or locally.

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/L414198.html