aladdin 阿拉丁 T414361 毛两面针素 483-90-9 98%

中文名：毛两面针素

英文名：Toddalolactone

纯度：≥98%

货号：T414361

Cas号：483-90-9

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Toddalolactone Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.

Targets

PAI-1 37.31 μM

In vitro

Toddalolactone inhibits the binding between PAI-1 and uPA, and therefore prevented the formation of the PAI-1/uPA complex.

In vivo

Intraperitoneal injection of toddalolactone in mice significantly prolonged tail bleeding and reduced arterial thrombus weight in a FeCl3-induced thrombosis model. Moreover, the hydroxyproline level in the plasma and the degree of liver fibrosis in mice were decreased after intraperitoneal injection of toddalolactone in CCl4-induced mouse liver fibrosis model.

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