aladdin 阿拉丁 H414466 HS-243 848249-10-5 98%

中文名：HS-243

英文名：HS-243

纯度：10mM in DMSO

货号：H580413

Cas号：848249-10-5

存储温度：-80℃储存

运输条件：特低温运输

产品介绍：

Information

HS-243 HS-243 is a highly potent interleukin-1 receptor-associated kinase (IRAK) inhibitor with IC50 of 24 nM, 20 nM and 0.5 μM for IRAK-1, IRAK-4 and TAK1, respectively.

Targets

IRAK-4 (Cell-free assay); IRAK-1 (Cell-free assay); TAK1 (Cell-free assay) 20 nM; 24 nM; 0.5 μM

In vitro

HS-243 has exquisite selectivity toward both IRAK-1 (IC50 = 24 nM) and IRAK-4 (IC50 = 20 nM), with only minimal TAK1-inhibiting activity (IC50 = 0.5 μM). Using HS-243 and takinib, we evaluates the consequences of cytokine/chemokine responses after selective inhibition of IRAK-1/4 or TAK1 in response to lipopolysaccharide challenge in human rheumatoid arthritis fibroblast-like synoviocytes. HS-243 specifically inhibits intracellular IRAKs without TAK1 inhibition and these kinases have distinct, nonredundant signaling roles.

Cell Research(from reference)

Cell lines：RA-FLS cells, THP-1 cells 

Concentrations：10 μM 

Incubation Time：24 h 

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/H580413.html