aladdin 阿拉丁 S413831 SRT2104 (GSK2245840) 1093403-33-8 98%

中文名：SRT2104 (GSK2245840)

英文名：SRT2104 (GSK2245840)

纯度：Moligand™，≥98%

货号：S413831

Cas号：1093403-33-8

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

SRT2104 (GSK2245840) is a selectiveSIRT1activator involved in the regulation of energy homeostasis. Phase 2.

Targets

SIRT1

In vitro

SRT2104 reduces p65/RelA acetylation levels in C2C12 cells.

In vivo

In male C57BL/6J mice, SRT2104 (100 mg/kg, p.o.) extends both mean and maximal lifespan of mice fed a standard diet, and enhances motor coordination, bone mineral density, and insulin sensitivity and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.

Cell Research(from reference)

Cell lines：C2C12 cell line 

Concentrations：3\xa0μM 

Incubation Time：24 h 

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