aladdin 阿拉丁 G414274 GSK2983559（化合物3） 1579965-12-0 98%

中文名：GSK2983559（化合物3）

英文名：GSK2983559 (compound 3)

纯度：Moligand™，≥98%

货号：G414274

Cas号：1579965-12-0

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

GSK2983559 (compound 3) GSK2983559 (compound 3, RIP2 kinase inhibitor 1, RIPK2-IN-1) is a potent inhibitor of receptor interacting protein 2 (RIP2) kinase with good kinase specificity.

Targets

RIP2 kinase

In vitro

In a screen against nonkinase targets (Eurofins, 104 receptor and ion channel binding assays and 35 enzyme and cell-based assays), GSK2983559 is highly selective, inhibiting only melatonin receptor MT3 at a concentration under 10 μM..

In vivo

Administration of GSK2983559 at the 7.5 and 145 mg/kg b.i.d doses exhibits efficacy similar to that of prednisolone as measured by summed colon scores in a murine 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced colitis model..

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