aladdin 阿拉丁 C413829 CDKI-73 1421693-22-2 95%

中文名：CDKI-73

英文名：CDKI-73

纯度：Moligand™，≥95%

货号：C413829

Cas号：1421693-22-2

存储温度：-20°C储存,充氩

运输条件：超低温运输

产品介绍：

Information

CDKI-73 (LS-007) is a potentCDKinhibitor in vitro with IC50 of 8.17 nM, 3.27 nM, 8.18 nM, and 5.78 nM for CDK1, CDK2, CDK4, and CDK9, respectively. CDKI-73 induces apoptosis in cancer cells. CDKI-73 is an orally bioavailable and highly efficaciousCDK9inhibitor against acute myeloid leukemia.

Targets

CDK2 (Cell-free assay); CDK9 (Cell-free assay); CDK1 (Cell-free assay); CDK4 (Cell-free assay) 3.27 nM; 5.78 nM; 8.17 nM; 8.18 nM

In vitro

CDKI-73 induces cancer cells undergoing apoptosis through transcriptional downregulation of anti-apoptotic proteins Bcl-2, Mcl-1 and XIAP by majorly targeting CDK9. Contrastively, it is relatively low toxic to the bone marrow cells of healthy donors.

In vivo

CDKI-73 is orally bioavailable, highly efficacious against MLL-AML MV4–11 xenografts and downregulates anti-apoptotic proteins by targeting CDK9 in vivo.

Cell Research(from reference)

Cell lines：Leukemia cell lines (MOLM13, MV4-11, THP-1, etc.) 

Concentrations：0.05 μM, 0.1 μM, 0.25 μM, 0.5 μM 

Incubation Time：1 h, 4 h, 12 h, 24 h, 48 h 

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