aladdin 阿拉丁 P334885 醋酸普兰林肽 196078-30-5 98%

中文名：醋酸普兰林肽

英文名：Pramlintide Acetate

英文别名：Tripo-amylin Acetate Hydrate; AC-137 Acetate Hydrate, Symlin Acetate Hydrate

纯度：98%

货号：P334885

包装：2.5mg、25mg、100mg

Cas号：196078-30-5

存储温度：-20°C储存

产品介绍：

product description： 

Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease.

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