aladdin 阿拉丁 L413816 LY2409881 trihydrochloride 946518-60-1 97%

中文名：LY2409881 trihydrochloride

英文名：LY2409881 trihydrochloride

英文别名：2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride

纯度：97%

货号：L413816

包装：100mg、5mg、25mg

Cas号：946518-60-1

存储温度：-20°C储存

产品介绍：

Information

LY2409881 is a potent and selectiveIKK2inhibitor withIC50of 30 nM, >10-fold selectivity over IKK1 and other common kinases.

Targets

IKK2 30 nM

In vitro

LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.

In vivo

In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth.

Cell Research(from reference)

Cell lines：OCI-LY10 cells 

Concentrations：25 μM 

Incubation Time：~72 h 

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