aladdin 阿拉丁 O413864 Onatasertib (CC 223) 1228013-30-6 99%

中文名：Onatasertib (CC 223)

英文名：Onatasertib (CC 223)

纯度：Moligand™，≥99%

货号：O413864

Cas号：1228013-30-6

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Onatasertib (CC 223) Onatasertib (CC 223) is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.

Targets

mTOR (Cell-free assay); cFMS (Cell-free assay); FLT4 (Cell-free assay); DNA-PK (Cell-free assay) 16 nM; 28 nM; 651 nM; 840 nM

In vitro

In a panel of cell lines, CC-223 inhibits both mTORC1 (S6RP and 4EBP1) and mTORC2 [AKT(S473)] markers with IC50 ranges of 27 to 184 nM for pS6RP, 120 to 1,050 nM for p4EBP1 and 11 to 150 nM for pAKT(S473), respectively. CC-223 also inhibits cell growth and induces apoptosis across a number of cancer cell lines.

In vivo

In PC-3 tumor-bearing mice, CC-223 (25 mg/kg, p.o.) inhibits both mTORC1 and mTORC2. CC-223 (25 mg/kg, p.o.) also results in tumor growth inhibition by 47% to 95% in xenograft models of prostate, glioma, breast, lung, and colon.

Cell Research(from reference)

Cell lines：PC-3, CAL-51, A549,T47D,NCI-H460, HepG2, AU565, Hep3B, HCC, U87MG, HCT116, MDA-MB-231, and NCI-H23 cells 

Concentrations：~ 10 μM 

Incubation Time：72 h 

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