aladdin 阿拉丁 D413069 盐酸去氢吴茱萸碱 111664-82-5 99%

中文名：盐酸去氢吴茱萸碱

英文名：Dehydroevodiamine hydrochloride

纯度：≥99%

货号：D413069

Cas号：111664-82-5

存储温度：避光,-20°C储存

运输条件：超低温运输

产品介绍：

Information

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibitAChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Targets

AChE

In vitro

Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. It decreases intracellular calcium levels in primary cortical neurons.

In vivo

Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors. DHED significantly improves learning and memory in the Aβ_1-42-infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production.

Cell Research(from reference)

Cell lines：primary cortical neurons 

Concentrations：0.5 and 1 µM 

Incubation Time：4 h 

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