aladdin 阿拉丁 R408134 RK-33 1070773-09-9 10mM in DMSO

中文名：RK-33

英文名：RK-33

英文别名：2H-​Diimidazo[4,​5-​d:4',​5'-​f]​[1,​3]​diazepin-​2-​one, 3,​7-​dihydro-​3,​7-​bis[(4-​methoxyphenyl)​methyl]​-

纯度：10mM in DMSO

货号：R408134

包装：1ml

Cas号：1070773-09-9

存储温度：-80℃储存

产品介绍：

Information

RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
In vitro

RK-33 binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17. RK-33 inhibits cancer growth and radiosensitizes lung cancer cells in a DDX3-dependent manner. RK-33 has no effect on either mitochondrial respiration or ATP generation. RK-33 curbs proliferation and induces apoptosis in a DDX3-dependent fashion. Wnt signaling is mediated by DDX3 and inhibited by RK-33. RK-33 impairs radiation-induced DNA damage repair by inhibiting NHEJ activity.

In vivo

RK-33 in combination with radiation induces tumor regression in multiple mouse models of lung cancer. RK-33, at the dose used, is non-toxic in SCID mice. RK-33-treated mice do not exhibit any discernable morphological changes.
Cell Data

cell lines：

Concentrations：7.5 μM

Incubation Time：12 h

Powder Purity:≥99%

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