aladdin 阿拉丁 D408674 达洛鲁胺 1297538-32-9 10mM in DMSO

中文名：达洛鲁胺

英文名：Darolutamide

纯度：Moligand™，≥99%

货号：D413782

Cas号：1297538-32-9

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Darolutamide (ODM-201) Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with K i of 11 nM. Phase 3.

Targets

Androgen receptor 11 nM(Ki)

In vitro

In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells.

In vivo

In mice bearing VCaP xenografts, ODM-201 (50\u2009mg/kg, p.o.) significantly inhibits castration-resistant prostate tumor growth.

Cell Research(from reference)

Cell lines：DU-145, H1581, and VCaP cells 

Concentrations：~10 μM 

Incubation Time：4 days 

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