aladdin 阿拉丁 I414168 IDF-11774 1429054-28-3 99%

中文名：IDF-11774

英文名：IDF-11774

纯度：≥99%

货号：I414168

Cas号：1429054-28-3

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

IDF-11774 IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.

Targets

HIF-1

In vitro

IDF-11774 inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells under hypoxic conditions. The treatment of IDF-11774 suppresses angiogenesis of cancer cells by reducing the expression of HIF-1 target genes, reduces glucose uptake, thereby sensitizing cells to growth under low glucose conditions, and decreases the extracellular acidification rate (ECAR) and oxygen consumption rate of cancer cells. Therefore, IDF-11774 reduces cancer cell growth through the regulation of cancer glycolytic metabolism and energy production.

In vivo

IDF-11774 exhibited substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations, which often occur in malignant cancers.

Cell Research(from reference)

Cell lines：HCT116 cells 

Concentrations：5, 10, 20 μM 

Incubation Time：18 h 

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/I414168.html