aladdin 阿拉丁 B115502 BML 283,Ca 2+螯合剂 126150-97-8 95%

中文名：BML 283,Ca 2+螯合剂

英文名：BAPTA-AM

中文别名：1,2-双(2-氨基苯氧基)乙烷-N,N,N`,N`-四乙酸四乙酸甲酯|胞内钙荧光探针BAPTA-AM|1,2-双(2-氨基苯氧基)乙烷-N,N,N',N'-四乙酸四(乙酸基甲基)酯|1,2-双(2-氨基苯氧基)-乙烷-N,N,N,N'-四乙酸

英文别名：BAPTA-AM|126150-97-8|BAPTA/AM|acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate|BAPTA/AM(BAPTA-AM)|(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}[2-(2-{2-[bis

纯度：95%

货号：B115502

包装：100mg、25mg

Cas号：126150-97-8

存储温度：-20°C储存

产品介绍：

BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid  is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C. Has also been shown to inhibit thapsigargin-induced apoptosis in rat thymocytes. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. 

BAPTA-AM抑制自由基介导的毒性，增强非神经细胞中细胞凋亡，保护神经细胞免受缺血性损伤。它调节离子通道，阻止神经Ca2+-激活K+通道电流。BAPTA-AM维持细胞内Ca2+动态平衡。

A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores.

· 降低剪切后半胱氨酸蛋白酶-3升高水平

· 阻止细胞死亡，抑制ROS（活性氧化簇）产物，抑制半胱氨酸蛋白酶-8活性。

· 排除细胞内Ca2+ ([Ca2+]i) 浓度变化对癫痫诱导影响

· 消除6-羟多巴胺(6-OHDA)诱导的[Ca2+]i增量水平

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/B115502.html