aladdin 阿拉丁 P414179 PQR620 1927857-56-4 97%

中文名：PQR620

英文名：PQR620

纯度：≥97%

货号：P414179

Cas号：1927857-56-4

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

PQR620 is a novel, selective, orally bioavailable and brain penetrant dualTORC1/2inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.

Targets

TORC1 (Cell-based assay); TORC2 (Cell-free assay) 250 nM; 250 nM

In vitro

PQR620 is a novel brain penetrant dual TORC1/2 inhibitor with anti-tumor activity across 56 lymphoma cell lines with a median IC50 value of 250 nM after 72 h of exposure.

In vivo

PQR620 has in vivo anti-lymphoma activity and in vivo synergism with the BCL2 inhibitor venetoclax. The combination of PQR620 and venetoclax have stronger in vivo anti-tumor activity than the single agents in a xenograft model of GCB-DLBCL.

Cell Research(from reference)

Cell lines：56 lymphoma cell lines, ABC-DLBCL cell lines (TMD8, Ri-1), GCB-DLBCL cell lines (OCI-LY-1,SU-DHL-6, DoHH2) 

Concentrations：2 μM 

Incubation Time：24 h, 72 h 

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