aladdin 阿拉丁 D130797 1,2-二硬脂酰基-sn-甘油-3-磷酸乙醇胺-N-[叶酸(聚乙二醇)-5000](铵盐) 1236288-25-7

中文名：1,2-二硬脂酰基-sn-甘油-3-磷酸乙醇胺-N-[叶酸(聚乙二醇)-5000](铵盐)

英文名：1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (ammonium salt)

中文别名：DSPE-PEG(5000) Folate

货号：D130797

包装：10mg、1mg、5mg

Cas号：1236288-25-7

存储温度：-20°C储存

产品介绍：

Folate receptors are cellular surface markers for numerous solid tumors and myeloid leukemias. Avanti now offers a derivative, DSPE-PEG-folate, which can be incorporated into liposomes as a targeting ligand. Folate targeted drμg delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small molecular size and high binding affinity for cell surface folate receptors (FR), folate conjμgates have the ability to deliver a variety of molecular complexes to pathologic cells without causing harm to normal tissues. Complexes that have been successfully delivered to FR expressing cells, to date, include protein toxins, immune stimulants, chemotherapeutic agents, liposomes, nanoparticles, and imaging agents. This review will summarize the applications of folic acid as a targeting ligand and highlight the various methods being developed for delivery of therapeutic and imaging agents to FR-expressing cells.

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