aladdin 阿拉丁 M126295 MK-6892 917910-45-3 98%

中文名：MK-6892

英文名：MK-6892

纯度：Moligand™，≥98%

货号：M126295

Cas号：917910-45-3

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

application：

Description: IC50 Value: 4.0 nM (Ki for Human GPR109A)  MK-6892 is a highly potential GPR109A agonists. in vitro: . Despite the increased serum shift of these compounds, the representative 1e was highly potent. Furthermore, these compounds had no activity on GPR109B and GPR81, the two most closely related GPCRs with ?96% and 50% sequence identity to GPR109A,respectively . in vivo: NA or MK-6892 was orally administered to WT or NA receptor null mice on the same C57Bl/6 genetic background. After 15 min of 100 mpk dosing of NA or MK-6892 to fed WT or NA receptor null mice, the blood levels of MK-6892 at 15 min were 229 μM (?950-fold greater than the in vitro EC50 determined in mouse NA receptor GTPγS assay, which is 240 nM) in WT mice and 148 μM (?620-fold greater than the in vitro EC50) in NA receptor null mice . Clinical trial: N/A 

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/M126295.html