aladdin 阿拉丁 B414218 BAY 2402234 2225819-06-5 99%

中文名：BAY 2402234

英文名：BAY 2402234

纯度：Moligand™，≥99%

货号：B414218

Cas号：2225819-06-5

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

BAY 2402234 BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.

Targets

DHODH (Cell-free assay) 1.2 nM

In vitro

BAY 2402234 induces differentiation and inhibits proliferation in AML cell lines across multiple AML subtypes.

In vivo

BAY 2402234 shows strong monotherapy efficacy and induces differentiation in AML xenograft models in vivo.

Cell Research(from reference)

Cell lines：MOLM-13, HEL, MV4-11, SKM-1 and THP-1 cell lines 

Concentrations：0.1nM to 1μM 

Incubation Time：96 h 

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