aladdin 阿拉丁 D413874 DASA-58 1203494-49-8 98%

中文名：DASA-58

英文名：DASA-58

纯度：Moligand™，≥98%

货号：D413874

Cas号：1203494-49-8

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

Targets

PKM2

In vitro

DASA-58 inhibits LPS-induced Hif-1α and IL-1β, as well as the expression of a range of other Hif-1α-dependent genes in primary BMDMs, and also inhibits glycolysis and the accumulation of succinate in LPS-activated macrophages. In PC3 cells, DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2, as well as its association with HIF-1α. DASA-58 also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells.

In vivo

DASA-58 (40 μM) affects EMT of prostate cancers and tumor dissemination in SCID mice.

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