aladdin 阿拉丁 R125138 利伐沙班 366789-02-8 ≥99%

中文名：利伐沙班

英文名：Rivaroxaban

中文别名：利伐沙班

英文别名：B01AF01|1429742-50-6|2-Thiophenecarboxamide, 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)phenyl)-5-oxazolidinyl)methyl)-|2w26|9NDF7JZ4M3|Q420262|Xarelto|MFCD11974010|N-Smc-carboxylate|L-Glutatione|RIVAROXABAN [ORANGE BOOK]|MLS006010027|Rivaroxaban|R

纯度：≥99%

货号：R125138

包装：10mg、50mg、250mg

Cas号：366789-02-8

存储温度：-20°C储存

产品介绍：

Rivaroxaban is an oral, direct inhibitor of Factor X, being developed for the prevention and treatment of arterial and venous thrombosis with a Ki of 0.4 nM. Rivaroxaban also inhibits prothrombinase activity (IC50 = 2.1 nM). Rivaroxaban also shows a similar affinity to purified human (IC50 = 0.7 nM) and rabbit Factor X (IC50 = 0.8 nM), but a lesser potency against purified rat Factor X (IC50 = 3.4 nM). Endogenous human and rabbit Factor X in plasma is inhibited to a similar extent by Rivaroxaban (IC50 = 21 nM and 21 nM, respectively), while 14-fold higher concentrations are required in rat plasma (IC50 = 290 nM). Rivaroxaban exhibits high permeability and polarized transport across Caco-2 cells as a substrate of the P-gp, but exhibits no inhibitory effect on P-gp-mediated drμg transport up to concentrations of 100 μM in vitro.

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