aladdin 阿拉丁 N130841 氯硝柳胺 50-65-7 98%

中文名：氯硝柳胺

英文名：Niclosamide

中文别名：2',5-二氯-4'-硝基水杨酸酰替苯胺

英文别名：niclosamide|50-65-7|5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide|Niclocide|Bayluscid|Phenasal|Cestocid|Devermin|Devermine|Helmiantin|Mansonil|Radeverm|Tredemine|Vermitid|Atenase|Fenasal|Iomesan|Iomezan|Lintex|Nasemo|Sagimid|Sulqui|Yomesan|Mato|F

纯度：98%

货号：N130841

包装：250g、50g、25g

Cas号：50-65-7

产品介绍：

Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.

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