MK-467

中文名称130466-38-5中文同义词化合物T13285英文名称Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride(1:1)英文同义词Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride(1:1);Vatinoxanhydrochloride;L-659066hydrochloride;MK-467hydrochlorideCAS号130466-38-5分子式C20H27ClN4O4S分子量454.97EINECS号相关类别Mol文件130466-38-5.mol结构式130466-38-5性质储存条件Storeat-20°C水溶解性Water:≥133mg/mL(292.33mM)130466-38-5用途与合成方法生物活性Vatinoxanhydrochloride(MK-467hydrochloride;L-659066hydrochloride)是一种外周α2肾上腺素能受体(α2adrenergicreceptor)拮抗剂。靶点α2adrenergicreceptor体内研究Vatinoxanaloneincreasescardiacindexandtissueoxygendeliveryandhasnodeleteriousadverseeffects.Vatinoxanattenuatesorpreventsdexmedetomidine’ssystemichemodynamiceffectsinadose-dependentmannerwhengivensimultaneouslyi.v.buthasnoeffectonthepulmonaryoutcomeinconsciousdogs.A50:1doseratio(Vatinoxan:dexmedetomidine)inducestheleastalterationsincardiovascularfunction.Vatinoxandose-dependentlyattenuatesthebradycardiaassociatedwithdexmedetomidine,andshortensthesedativeeffectwithoutalteringitsquality.Vatinoxanmaybeusefulinattenuatingreductionsinheartrateinconsciouscatsadministereddexmedetomidine.